Undergrad Thesis

After four years of majoring in Biochemistry and Molecular Biology, I wrote an undergraduate thesis!  It might not be very accessible or interesting to people outside of my particular field, but feel free to take a look and ask me any questions you want.  Read it at this link: David Reich biochemistry thesis

Ligand Binding at the IP3-Binding Core of the IP3 Receptor

In the fall semester of 2016, I took a class called Chemical Biology, a small upper-level lecture in the Chemistry department.  It was probably the most difficult class of my undergraduate career, and my final paper was one of the projects of which I am most proud.  I set out, in my prospectus, to approach the chemical biology of calcium signaling: the various ways in which researchers use chemical tools to understand the biology of the calcium ion as an agent of communication between systems within cells.  Upon beginning to write, it quickly became clear that the topic was infinitely larger than I had expected.  The entire paper became concerned with understanding the chemical interaction between a particular protein and its biological small molecule ligand – an interaction critical to the release of the calcium ion under many circumstances, and representing one of the best opportunities for its study.

Download and read my paper on the subject at the following link: IP3-binding.

UTRA Summer 2016

In the summer of 2016, I worked in the Jeffrey Morgan laboratory on an UTRA (Undergraduate Teaching and Research Award) project.

I investigated the optimal conditions for use of an Eppendorf automatic liquid handler for the seeding of cell suspensions into 2nd-generation Microtissue microgels.  By the end of the project, I had achieved a reliability of spheroid formation comparable to that of spheroids seeded by the hand of a trained researcher, but requiring much less time and effort.

My final poster is available at the following link: UTRA-2016-poster